Drug interactions
Ifosfamide + Istradefylline
Severity: Minor
Ifosfamide and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg/day istradefylline raises exposure of CYP3A4 substrates, which could alter ifosfamide metabolism. The direction of the clinical effect is uncertain, and the effect is not seen at 20 mg/day.
What this interaction means in plain words
Ifosfamide and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ifosfamide belongs to Oncology; Istradefylline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by istradefylline at higher doses alters ifosfamide metabolism.
What to do
No routine adjustment is needed; monitor for neurotoxicity and response, particularly if istradefylline 40 mg/day is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Ifosfamide with Istradefylline?
MediHelp rates the interaction as minor. Ifosfamide and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg/day istradefylline raises exposure of CYP3A4 substrates, which could alter ifosfamide metabolism. The direction of the clinical effect is uncertain, and the effect is not seen at 20 mg/day.
How serious is the interaction between Ifosfamide and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for neurotoxicity and response, particularly if istradefylline 40 mg/day is used.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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