Drug interactions
Ifosfamide + Lorlatinib
Severity: Moderate
Ifosfamide and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a CYP3A4 inducer, so it may increase ifosfamide metabolism, including formation of neurotoxic and nephrotoxic metabolites. The legacy direction of effect is questionable, and the result may be altered efficacy or toxicity.
What this interaction means in plain words
Ifosfamide and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induction of CYP3A4 may increase ifosfamide metabolism.
What to do
Monitor for neurotoxicity, renal toxicity and myelosuppression, and adjust ifosfamide dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Ifosfamide with Lorlatinib?
MediHelp rates the interaction as moderate. Ifosfamide and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib is a CYP3A4 inducer, so it may increase ifosfamide metabolism, including formation of neurotoxic and nephrotoxic metabolites. The legacy direction of effect is questionable, and the result may be altered efficacy or toxicity.
How serious is the interaction between Ifosfamide and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurotoxicity, renal toxicity and myelosuppression, and adjust ifosfamide dose if toxicity occurs.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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