Drug interactions
Ifosfamide + Mechlorethamine
Severity: Moderate
Ifosfamide and Mechlorethamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are alkylating agents that cause myelosuppression and immunosuppression. Combined use can deepen cytopenias and raise infection and bleeding risk.
What this interaction means in plain words
Ifosfamide and Mechlorethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Mechlorethamine belongs to Oncology.
Why it happens
Additive pharmacodynamic bone marrow suppression from two alkylating agents.
What to do
Monitor complete blood counts frequently and adjust doses or delay cycles for neutropenia or thrombocytopenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Ifosfamide with Mechlorethamine?
MediHelp rates the interaction as moderate. Ifosfamide and Mechlorethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are alkylating agents that cause myelosuppression and immunosuppression. Combined use can deepen cytopenias and raise infection and bleeding risk.
How serious is the interaction between Ifosfamide and Mechlorethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and adjust doses or delay cycles for neutropenia or thrombocytopenia.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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