Drug interactions
Ifosfamide + Metformin-pioglitazone
Severity: Moderate
Ifosfamide and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone is not a clinically relevant CYP3A4 inducer, so the proposed effect on ifosfamide activation is unlikely. Ifosfamide itself can cause nephrotoxicity, including tubular injury, which could in principle impair metformin clearance and raise lactic acidosis risk.
What this interaction means in plain words
Ifosfamide and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Ifosfamide-induced renal tubular toxicity may reduce metformin elimination; no meaningful CYP3A4 induction by pioglitazone.
What to do
Monitor renal function during ifosfamide treatment and hold metformin if renal function deteriorates significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Ifosfamide and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pioglitazone is not a clinically relevant CYP3A4 inducer, so the proposed effect on ifosfamide activation is unlikely. Ifosfamide itself can cause nephrotoxicity, including tubular injury, which could in principle impair metformin clearance and raise lactic acidosis risk.
How serious is the interaction between Ifosfamide and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function during ifosfamide treatment and hold metformin if renal function deteriorates significantly.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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