Drug interactions
Ifosfamide + Miconazole
Severity: Moderate
Ifosfamide and Miconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic miconazole inhibits CYP enzymes involved in ifosfamide activation and may reduce its effectiveness. Metabolite-related toxicity could shift as well.
What this interaction means in plain words
Ifosfamide and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibition of CYP2B6 and CYP3A4-mediated ifosfamide metabolism.
What to do
Avoid systemic miconazole with ifosfamide where possible, and use another antifungal with less CYP inhibition. Monitor response and toxicity if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Miconazole
Frequently asked questions
Can I take Ifosfamide with Miconazole?
MediHelp rates the interaction as moderate. Ifosfamide and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic miconazole inhibits CYP enzymes involved in ifosfamide activation and may reduce its effectiveness. Metabolite-related toxicity could shift as well.
How serious is the interaction between Ifosfamide and Miconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic miconazole with ifosfamide where possible, and use another antifungal with less CYP inhibition. Monitor response and toxicity if combined.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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