Drug interactions
Ifosfamide + Oxcarbazepine
Severity: Moderate
Ifosfamide and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
CYP3A4 inducers can increase conversion of ifosfamide to active alkylating metabolites and to chloroacetaldehyde, which is neurotoxic and nephrotoxic. This may raise toxicity while altering efficacy.
What this interaction means in plain words
Ifosfamide and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Oxcarbazepine induces CYP3A4, shifting ifosfamide metabolism toward activation and chloroacetaldehyde formation.
What to do
Monitor for neurotoxicity, renal function and myelosuppression. Consider an alternative non-inducing antiepileptic and adjust the ifosfamide dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ifosfamide and Oxcarbazepine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Oxcarbazepine?
MediHelp rates the interaction as moderate. Ifosfamide and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. CYP3A4 inducers can increase conversion of ifosfamide to active alkylating metabolites and to chloroacetaldehyde, which is neurotoxic and nephrotoxic. This may raise toxicity while altering efficacy.
How serious is the interaction between Ifosfamide and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurotoxicity, renal function and myelosuppression. Consider an alternative non-inducing antiepileptic and adjust the ifosfamide dose if toxicity develops.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
