Drug interactions
Ifosfamide + Palifermin
Severity: Major
Ifosfamide and Palifermin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin promotes epithelial proliferation, which may make mucosal cells more sensitive to cytotoxic chemotherapy. Close timing has been associated with more severe and longer oral mucositis.
What this interaction means in plain words
Ifosfamide and Palifermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ifosfamide belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin-induced epithelial proliferation increases mucosal susceptibility to cytotoxic chemotherapy.
What to do
Do not give palifermin within 24 hours before, during, or within 24 hours after ifosfamide. Monitor for mucositis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Palifermin
Frequently asked questions
Can I take Ifosfamide with Palifermin?
MediHelp rates the interaction as major. Ifosfamide and Palifermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palifermin promotes epithelial proliferation, which may make mucosal cells more sensitive to cytotoxic chemotherapy. Close timing has been associated with more severe and longer oral mucositis.
How serious is the interaction between Ifosfamide and Palifermin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during, or within 24 hours after ifosfamide. Monitor for mucositis.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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