Drug interactions
Ifosfamide + Trabectedin
Severity: Moderate
Ifosfamide and Trabectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ifosfamide and trabectedin can cause cardiomyopathy, and trabectedin additionally causes hepatotoxicity and myelosuppression. Combined use can increase the risk of reduced cardiac function and of cytopenias.
What this interaction means in plain words
Ifosfamide and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Trabectedin belongs to Oncology.
Why it happens
Additive cardiotoxicity and myelosuppression.
What to do
Assess left ventricular ejection fraction before and periodically during therapy, and monitor liver enzymes and blood counts. Stop or reduce trabectedin if cardiac function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Trabectedin
Frequently asked questions
Can I take Ifosfamide with Trabectedin?
MediHelp rates the interaction as moderate. Ifosfamide and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both ifosfamide and trabectedin can cause cardiomyopathy, and trabectedin additionally causes hepatotoxicity and myelosuppression. Combined use can increase the risk of reduced cardiac function and of cytopenias.
How serious is the interaction between Ifosfamide and Trabectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess left ventricular ejection fraction before and periodically during therapy, and monitor liver enzymes and blood counts. Stop or reduce trabectedin if cardiac function declines.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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