Drug interactions
Ifosfamide + Trastuzumab
Severity: Moderate
Ifosfamide and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab added to myelosuppressive chemotherapy has been associated with higher rates of neutropenia and febrile neutropenia. Ifosfamide adds its own marrow toxicity, raising infection risk.
What this interaction means in plain words
Ifosfamide and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive hematologic toxicity; trastuzumab appears to worsen chemotherapy-induced neutropenia by a mechanism that is not fully established.
What to do
Monitor neutrophil counts and infection signs, and use dose delays or G-CSF support per protocol. Also follow cardiac function as per trastuzumab labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Trastuzumab
Frequently asked questions
Can I take Ifosfamide with Trastuzumab?
MediHelp rates the interaction as moderate. Ifosfamide and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab added to myelosuppressive chemotherapy has been associated with higher rates of neutropenia and febrile neutropenia. Ifosfamide adds its own marrow toxicity, raising infection risk.
How serious is the interaction between Ifosfamide and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and infection signs, and use dose delays or G-CSF support per protocol. Also follow cardiac function as per trastuzumab labeling.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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