Drug interactions
Iloprost inhaled + Warfarin
Severity: Moderate
Iloprost inhaled and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost inhibits platelet aggregation. With warfarin, bleeding risk may rise, although systemic exposure after inhalation is limited.
What this interaction means in plain words
Iloprost inhaled and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect of prostacyclin analog platelet inhibition and anticoagulation.
What to do
Monitor for bleeding and follow INR routinely. Report signs of hemoptysis or other bleeding promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Iloprost inhaled with Warfarin?
MediHelp rates the interaction as moderate. Iloprost inhaled and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloprost inhibits platelet aggregation. With warfarin, bleeding risk may rise, although systemic exposure after inhalation is limited.
How serious is the interaction between Iloprost inhaled and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and follow INR routinely. Report signs of hemoptysis or other bleeding promptly.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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