Drug interactions
Imatinib + Infigratinib
Severity: Moderate
Imatinib and Infigratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may increase infigratinib exposure through CYP3A4 inhibition. This may worsen hyperphosphatemia, ocular toxicity and other dose-related adverse effects.
What this interaction means in plain words
Imatinib and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of infigratinib.
What to do
Use an alternative to imatinib if possible; otherwise monitor serum phosphate and ophthalmic symptoms and adjust the infigratinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Infigratinib?
MediHelp rates the interaction as moderate. Imatinib and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may increase infigratinib exposure through CYP3A4 inhibition. This may worsen hyperphosphatemia, ocular toxicity and other dose-related adverse effects.
How serious is the interaction between Imatinib and Infigratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative to imatinib if possible; otherwise monitor serum phosphate and ophthalmic symptoms and adjust the infigratinib dose if toxicity occurs.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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