Drug interactions
Imatinib + Irinotecan liposomal
Severity: Major
Imatinib and Irinotecan liposomal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4, which converts irinotecan to inactive metabolites, and may also inhibit UGT1A1, increasing exposure to the active metabolite SN-38. This may worsen neutropenia and diarrhea.
What this interaction means in plain words
Imatinib and Irinotecan liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Imatinib inhibits CYP3A4 and may inhibit UGT1A1, raising irinotecan and SN-38 exposure.
What to do
Monitor blood counts and diarrhea closely and consider irinotecan dose reduction; avoid the combination if alternatives exist.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Irinotecan liposomal?
MediHelp rates the interaction as major. Imatinib and Irinotecan liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imatinib inhibits CYP3A4, which converts irinotecan to inactive metabolites, and may also inhibit UGT1A1, increasing exposure to the active metabolite SN-38. This may worsen neutropenia and diarrhea.
How serious is the interaction between Imatinib and Irinotecan liposomal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and diarrhea closely and consider irinotecan dose reduction; avoid the combination if alternatives exist.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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