Drug interactions
Imatinib + Isoniazid
Severity: Moderate
Imatinib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is metabolized mainly by CYP3A4, which isoniazid may inhibit weakly. Increased imatinib exposure could worsen fluid retention, myelosuppression and hepatotoxicity. Both drugs can also injure the liver.
What this interaction means in plain words
Imatinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak CYP3A4 inhibition by isoniazid plus additive hepatotoxicity.
What to do
Monitor liver enzymes and blood counts regularly. Reduce the imatinib dose or interrupt therapy if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Isoniazid?
MediHelp rates the interaction as moderate. Imatinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib is metabolized mainly by CYP3A4, which isoniazid may inhibit weakly. Increased imatinib exposure could worsen fluid retention, myelosuppression and hepatotoxicity. Both drugs can also injure the liver.
How serious is the interaction between Imatinib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and blood counts regularly. Reduce the imatinib dose or interrupt therapy if toxicity occurs.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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