Drug interactions
Imatinib + Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate
Severity: Minor
Imatinib and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 and may increase exposure to ethinylestradiol and levonorgestrel. The clinical effect is likely modest, with possible estrogenic adverse effects. Imatinib is also teratogenic, so reliable contraception is important.
What this interaction means in plain words
Imatinib and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Imatinib inhibits CYP3A4 involved in the metabolism of ethinylestradiol and levonorgestrel.
What to do
No dose change is typically required; monitor for estrogen-related adverse effects and counsel on contraceptive reliability during imatinib treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate?
MediHelp rates the interaction as minor. Imatinib and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib inhibits CYP3A4 and may increase exposure to ethinylestradiol and levonorgestrel. The clinical effect is likely modest, with possible estrogenic adverse effects. Imatinib is also teratogenic, so reliable contraception is important.
How serious is the interaction between Imatinib and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is typically required; monitor for estrogen-related adverse effects and counsel on contraceptive reliability during imatinib treatment.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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