Drug interactions
Imatinib + Lumacaftor / ivacaftor
Severity: Moderate
Imatinib and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and can lower imatinib concentrations, risking reduced efficacy. Imatinib may raise ivacaftor exposure, but the net effect at steady state is not expected to exceed standard ivacaftor exposure.
What this interaction means in plain words
Imatinib and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces CYP3A4, increasing imatinib clearance, while imatinib inhibits CYP3A4 metabolism of ivacaftor.
What to do
Monitor imatinib response, consider imatinib dose increase or therapeutic drug monitoring, and no ivacaftor dose adjustment is generally needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Imatinib and Lumacaftor / ivacaftor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Imatinib and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and can lower imatinib concentrations, risking reduced efficacy. Imatinib may raise ivacaftor exposure, but the net effect at steady state is not expected to exceed standard ivacaftor exposure.
How serious is the interaction between Imatinib and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor imatinib response, consider imatinib dose increase or therapeutic drug monitoring, and no ivacaftor dose adjustment is generally needed.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
