Drug interactions
Imatinib + Meclofenamate
Severity: Moderate
Imatinib and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause thrombocytopenia and gastrointestinal bleeding, and meclofenamate, an NSAID, impairs platelet function and irritates the gastric mucosa. Together the risk of bleeding is increased.
What this interaction means in plain words
Imatinib and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bleeding risk from imatinib-induced thrombocytopenia and NSAID antiplatelet and mucosal effects.
What to do
Avoid NSAIDs where possible, using paracetamol instead, and monitor the platelet count and signs of gastrointestinal bleeding if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Meclofenamate?
MediHelp rates the interaction as moderate. Imatinib and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause thrombocytopenia and gastrointestinal bleeding, and meclofenamate, an NSAID, impairs platelet function and irritates the gastric mucosa. Together the risk of bleeding is increased.
How serious is the interaction between Imatinib and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible, using paracetamol instead, and monitor the platelet count and signs of gastrointestinal bleeding if combined.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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