Drug interactions
Imatinib + Midazolam intranasal
Severity: Moderate
Imatinib and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib raises systemic exposure to midazolam by inhibiting its metabolism. Sedation can be deeper and longer, with a risk of respiratory depression.
What this interaction means in plain words
Imatinib and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Imatinib inhibits CYP3A4-mediated midazolam metabolism.
What to do
Monitor sedation level and respiratory status for longer after the dose. Avoid repeat dosing or additional sedatives where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Midazolam intranasal?
MediHelp rates the interaction as moderate. Imatinib and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib raises systemic exposure to midazolam by inhibiting its metabolism. Sedation can be deeper and longer, with a risk of respiratory depression.
How serious is the interaction between Imatinib and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status for longer after the dose. Avoid repeat dosing or additional sedatives where possible.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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