Drug interactions
Imatinib + Mobocertinib
Severity: Major
Imatinib and Mobocertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may raise mobocertinib exposure, which has dose-related QTc prolongation and arrhythmia risk. Diarrhea and other toxicities may also increase.
What this interaction means in plain words
Imatinib and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Imatinib inhibits CYP3A4 metabolism of mobocertinib, and both drugs can prolong QT.
What to do
Avoid if possible. If unavoidable, reduce the mobocertinib dose by about half and monitor QTc and electrolytes closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Mobocertinib?
MediHelp rates the interaction as major. Imatinib and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imatinib may raise mobocertinib exposure, which has dose-related QTc prolongation and arrhythmia risk. Diarrhea and other toxicities may also increase.
How serious is the interaction between Imatinib and Mobocertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce the mobocertinib dose by about half and monitor QTc and electrolytes closely.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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