Drug interactions
Imatinib + Nafcillin
Severity: Moderate
Imatinib and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin may induce CYP3A4 and lower imatinib concentrations. Reduced exposure could compromise response in leukemia or GIST. The magnitude is uncertain and based mainly on inference from its inducing effect.
What this interaction means in plain words
Imatinib and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 increases imatinib metabolism.
What to do
Use a non-inducing antibiotic where possible. If combined, monitor clinical and molecular response and consider imatinib dose adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Nafcillin?
MediHelp rates the interaction as moderate. Imatinib and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin may induce CYP3A4 and lower imatinib concentrations. Reduced exposure could compromise response in leukemia or GIST. The magnitude is uncertain and based mainly on inference from its inducing effect.
How serious is the interaction between Imatinib and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing antibiotic where possible. If combined, monitor clinical and molecular response and consider imatinib dose adjustment.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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