Drug interactions
Imatinib + Nefazodone
Severity: Major
Imatinib and Nefazodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and can increase imatinib exposure, raising the risk of toxicity. Nefazodone itself carries hepatotoxicity risk, which may compound imatinib liver effects.
What this interaction means in plain words
Imatinib and Nefazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Nefazodone inhibits CYP3A4 metabolism of imatinib and may inhibit P-glycoprotein.
What to do
Avoid the combination and choose another antidepressant such as sertraline; if unavoidable, monitor liver function and consider reducing the imatinib dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Nefazodone?
MediHelp rates the interaction as major. Imatinib and Nefazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nefazodone is a strong CYP3A4 inhibitor and can increase imatinib exposure, raising the risk of toxicity. Nefazodone itself carries hepatotoxicity risk, which may compound imatinib liver effects.
How serious is the interaction between Imatinib and Nefazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another antidepressant such as sertraline; if unavoidable, monitor liver function and consider reducing the imatinib dose.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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