Drug interactions
Imatinib + Nirogacestat
Severity: Major
Imatinib and Nirogacestat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may raise nirogacestat concentrations, increasing diarrhea, hepatotoxicity, ovarian toxicity and other adverse effects.
What this interaction means in plain words
Imatinib and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imatinib belongs to Oncology; Nirogacestat belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4, a main pathway of nirogacestat metabolism.
What to do
Avoid the combination where possible. If it is needed, reduce the nirogacestat dose per labeling for moderate CYP3A inhibitors and monitor liver tests and diarrhea.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Nirogacestat
Frequently asked questions
Can I take Imatinib with Nirogacestat?
MediHelp rates the interaction as major. Imatinib and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imatinib may raise nirogacestat concentrations, increasing diarrhea, hepatotoxicity, ovarian toxicity and other adverse effects.
How serious is the interaction between Imatinib and Nirogacestat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is needed, reduce the nirogacestat dose per labeling for moderate CYP3A inhibitors and monitor liver tests and diarrhea.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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