Drug interactions
Imatinib + Ofatumumab sc
Severity: Moderate
Imatinib and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can impair immune defenses, imatinib through myelosuppression and ofatumumab through B-cell depletion. Concurrent use may increase the risk of infections, including serious or opportunistic ones. Subcutaneous ofatumumab is used for multiple sclerosis, so the combination is uncommon.
What this interaction means in plain words
Imatinib and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression and cytopenias through different pharmacodynamic mechanisms.
What to do
Check for active infection and hepatitis B status before starting, and monitor blood counts and infection signs throughout. Consider whether ofatumumab is needed while imatinib is being given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Ofatumumab sc?
MediHelp rates the interaction as moderate. Imatinib and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can impair immune defenses, imatinib through myelosuppression and ofatumumab through B-cell depletion. Concurrent use may increase the risk of infections, including serious or opportunistic ones. Subcutaneous ofatumumab is used for multiple sclerosis, so the combination is uncommon.
How serious is the interaction between Imatinib and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check for active infection and hepatitis B status before starting, and monitor blood counts and infection signs throughout. Consider whether ofatumumab is needed while imatinib is being given.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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