Drug interactions
Imatinib + Olaparib
Severity: Moderate
Imatinib and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may increase olaparib exposure, raising the risk of anemia, neutropenia, nausea and fatigue.
What this interaction means in plain words
Imatinib and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Olaparib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4, the main enzyme metabolizing olaparib.
What to do
If the combination cannot be avoided, reduce the olaparib dose as labeled for moderate CYP3A inhibitors and monitor blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Imatinib with Olaparib?
MediHelp rates the interaction as moderate. Imatinib and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may increase olaparib exposure, raising the risk of anemia, neutropenia, nausea and fatigue.
How serious is the interaction between Imatinib and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If the combination cannot be avoided, reduce the olaparib dose as labeled for moderate CYP3A inhibitors and monitor blood counts.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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