Drug interactions
Imatinib + Parecoxib
Severity: Moderate
Imatinib and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to valdecoxib, which is cleared partly by CYP2C9 and CYP3A4. Imatinib inhibits CYP2C9 only weakly and CYP3A4 moderately, so a modest increase in valdecoxib exposure is possible. Separately, NSAIDs can increase gastrointestinal bleeding and fluid retention, which are also concerns with imatinib.
What this interaction means in plain words
Imatinib and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Imatinib inhibits CYP3A4 and CYP2C9, potentially reducing valdecoxib clearance, alongside overlapping toxicities.
What to do
Use the lowest effective parecoxib dose for the shortest time. Monitor for gastrointestinal bleeding, edema and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Parecoxib?
MediHelp rates the interaction as moderate. Imatinib and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib is converted to valdecoxib, which is cleared partly by CYP2C9 and CYP3A4. Imatinib inhibits CYP2C9 only weakly and CYP3A4 moderately, so a modest increase in valdecoxib exposure is possible. Separately, NSAIDs can increase gastrointestinal bleeding and fluid retention, which are also concerns with imatinib.
How serious is the interaction between Imatinib and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective parecoxib dose for the shortest time. Monitor for gastrointestinal bleeding, edema and renal function.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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