Drug interactions
Imatinib + Promazine
Severity: Minor
Imatinib and Promazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may inhibit CYP2D6 and increase promazine exposure. This could increase sedation, hypotension and QT effects.
What this interaction means in plain words
Imatinib and Promazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Imatinib inhibits CYP2D6, reducing promazine clearance.
What to do
Monitor for sedation and orthostasis; reduce the promazine dose if effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Promazine?
MediHelp rates the interaction as minor. Imatinib and Promazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib may inhibit CYP2D6 and increase promazine exposure. This could increase sedation, hypotension and QT effects.
How serious is the interaction between Imatinib and Promazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostasis; reduce the promazine dose if effects emerge.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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