Drug interactions
Imatinib + Propranolol
Severity: Moderate
Imatinib and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6 and may increase propranolol concentrations, with greater beta-blockade such as bradycardia and hypotension. The clinical effect is generally modest because propranolol is cleared by several pathways.
What this interaction means in plain words
Imatinib and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Propranolol belongs to Cardiovascular.
Why it happens
Imatinib inhibition of CYP2D6 reduces propranolol hepatic metabolism.
What to do
Monitor heart rate and blood pressure when imatinib is started or stopped. Lower the propranolol dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Propranolol?
MediHelp rates the interaction as moderate. Imatinib and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP2D6 and may increase propranolol concentrations, with greater beta-blockade such as bradycardia and hypotension. The clinical effect is generally modest because propranolol is cleared by several pathways.
How serious is the interaction between Imatinib and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when imatinib is started or stopped. Lower the propranolol dose if bradycardia or hypotension occurs.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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