Drug interactions
Imatinib + Quercetin
Severity: Minor
Imatinib and Quercetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quercetin is a dietary flavonoid supplement that can modulate drug transporters and CYP enzymes in vitro. Its effect on imatinib exposure in patients is not established and is probably small.
What this interaction means in plain words
Imatinib and Quercetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible modulation of P-glycoprotein, BCRP and CYP3A4; the direction and size of the effect are not well established.
What to do
Advise patients to avoid high-dose quercetin supplements during imatinib therapy. Monitor treatment response and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Quercetin?
MediHelp rates the interaction as minor. Imatinib and Quercetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quercetin is a dietary flavonoid supplement that can modulate drug transporters and CYP enzymes in vitro. Its effect on imatinib exposure in patients is not established and is probably small.
How serious is the interaction between Imatinib and Quercetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid high-dose quercetin supplements during imatinib therapy. Monitor treatment response and tolerability.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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