Drug interactions
Imatinib + Reteplase
Severity: Moderate
Imatinib and Reteplase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reteplase is a thrombolytic with a high inherent bleeding risk, and imatinib may cause thrombocytopenia. Combined use can increase the likelihood or severity of hemorrhage.
What this interaction means in plain words
Imatinib and Reteplase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: fibrinolysis by reteplase on top of imatinib-induced thrombocytopenia.
What to do
Check the platelet count before thrombolysis and monitor closely for bleeding. Withhold thrombolysis if there is severe thrombocytopenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Reteplase?
MediHelp rates the interaction as moderate. Imatinib and Reteplase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Reteplase is a thrombolytic with a high inherent bleeding risk, and imatinib may cause thrombocytopenia. Combined use can increase the likelihood or severity of hemorrhage.
How serious is the interaction between Imatinib and Reteplase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the platelet count before thrombolysis and monitor closely for bleeding. Withhold thrombolysis if there is severe thrombocytopenia.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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