Drug interactions
Imatinib + Selumetinib
Severity: Moderate
Imatinib and Selumetinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may increase selumetinib exposure, raising the risk of gastrointestinal effects, rash, ocular toxicity and cardiomyopathy.
What this interaction means in plain words
Imatinib and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Selumetinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4, a main pathway of selumetinib metabolism.
What to do
Reduce the selumetinib dose per labeling for moderate CYP3A inhibitors and monitor for adverse effects. Restore the dose after stopping imatinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Selumetinib
Frequently asked questions
Can I take Imatinib with Selumetinib?
MediHelp rates the interaction as moderate. Imatinib and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may increase selumetinib exposure, raising the risk of gastrointestinal effects, rash, ocular toxicity and cardiomyopathy.
How serious is the interaction between Imatinib and Selumetinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the selumetinib dose per labeling for moderate CYP3A inhibitors and monitor for adverse effects. Restore the dose after stopping imatinib.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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