Drug interactions
Imatinib + Sofosbuvir / velpatasvir
Severity: Minor
Imatinib and Sofosbuvir / velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits BCRP and P-glycoprotein, which may modestly raise imatinib exposure. Clinical consequences are probably small, but imatinib adverse effects could be more frequent.
What this interaction means in plain words
Imatinib and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Velpatasvir inhibits intestinal BCRP and P-glycoprotein efflux of imatinib.
What to do
No dose change is routinely needed; monitor for imatinib adverse effects such as edema, cytopenias and gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as minor. Imatinib and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir inhibits BCRP and P-glycoprotein, which may modestly raise imatinib exposure. Clinical consequences are probably small, but imatinib adverse effects could be more frequent.
How serious is the interaction between Imatinib and Sofosbuvir / velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for imatinib adverse effects such as edema, cytopenias and gastrointestinal upset.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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