Drug interactions
Imatinib + Trifluoperazine
Severity: Minor
Imatinib and Trifluoperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may inhibit CYP2D6 and increase trifluoperazine exposure, increasing sedation, extrapyramidal effects and QT risk.
What this interaction means in plain words
Imatinib and Trifluoperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Imatinib inhibits CYP2D6, reducing trifluoperazine metabolism.
What to do
Monitor for extrapyramidal symptoms and sedation, and lower the trifluoperazine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Trifluoperazine?
MediHelp rates the interaction as minor. Imatinib and Trifluoperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib may inhibit CYP2D6 and increase trifluoperazine exposure, increasing sedation, extrapyramidal effects and QT risk.
How serious is the interaction between Imatinib and Trifluoperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and sedation, and lower the trifluoperazine dose if needed.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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