Drug interactions
Imatinib + Umeclidinium bromide / vilanterol inhaled
Severity: Minor
Imatinib and Umeclidinium bromide / vilanterol inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may raise systemic vilanterol exposure through CYP3A4 inhibition. This may cause more beta-agonist effects such as tachycardia, tremor and hypokalemia.
What this interaction means in plain words
Imatinib and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Imatinib inhibits CYP3A4 metabolism of vilanterol.
What to do
Monitor heart rate, palpitations and potassium. Consider a dose reduction or alternative if beta-agonist toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as minor. Imatinib and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib may raise systemic vilanterol exposure through CYP3A4 inhibition. This may cause more beta-agonist effects such as tachycardia, tremor and hypokalemia.
How serious is the interaction between Imatinib and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, palpitations and potassium. Consider a dose reduction or alternative if beta-agonist toxicity appears.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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