Drug interactions
Imatinib + Vorapaxar
Severity: Moderate
Imatinib and Vorapaxar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may increase vorapaxar exposure through CYP3A4 inhibition. Because vorapaxar is an antiplatelet agent, higher levels may increase bleeding risk.
What this interaction means in plain words
Imatinib and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of vorapaxar.
What to do
Monitor for bleeding signs and reassess the need for vorapaxar, particularly with other agents affecting hemostasis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Vorapaxar?
MediHelp rates the interaction as moderate. Imatinib and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may increase vorapaxar exposure through CYP3A4 inhibition. Because vorapaxar is an antiplatelet agent, higher levels may increase bleeding risk.
How serious is the interaction between Imatinib and Vorapaxar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and reassess the need for vorapaxar, particularly with other agents affecting hemostasis.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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