Drug interactions
Imatinib + Zanubrutinib
Severity: Moderate
Imatinib and Zanubrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may increase zanubrutinib exposure by inhibiting CYP3A4. This may increase bleeding, cytopenias and infection risk.
What this interaction means in plain words
Imatinib and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Zanubrutinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of zanubrutinib.
What to do
Reduce zanubrutinib to the labeled lower dose while on the moderate CYP3A inhibitor. Monitor blood counts and bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Zanubrutinib
Frequently asked questions
Can I take Imatinib with Zanubrutinib?
MediHelp rates the interaction as moderate. Imatinib and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may increase zanubrutinib exposure by inhibiting CYP3A4. This may increase bleeding, cytopenias and infection risk.
How serious is the interaction between Imatinib and Zanubrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce zanubrutinib to the labeled lower dose while on the moderate CYP3A inhibitor. Monitor blood counts and bleeding.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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