Drug interactions
Imipenem / cilastatin / relebactam + Probenecid
Severity: Moderate
Imipenem / cilastatin / relebactam and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces renal tubular secretion of imipenem and relebactam, raising their exposure. This offers no clear benefit and may increase the risk of adverse effects such as seizures.
What this interaction means in plain words
Imipenem / cilastatin / relebactam and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probenecid inhibits renal tubular secretion (OAT-mediated) of imipenem and relebactam.
What to do
Avoid routine coadministration. If unavoidable, monitor for neurotoxicity and adjust for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Imipenem / cilastatin / relebactam with Probenecid?
MediHelp rates the interaction as moderate. Imipenem / cilastatin / relebactam and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces renal tubular secretion of imipenem and relebactam, raising their exposure. This offers no clear benefit and may increase the risk of adverse effects such as seizures.
How serious is the interaction between Imipenem / cilastatin / relebactam and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine coadministration. If unavoidable, monitor for neurotoxicity and adjust for renal function.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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