Drug interactions
Imipramine + Isoflurane
Severity: Moderate
Imipramine and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval and cause hypotension, and imipramine may add to arrhythmia risk and blood pressure lability during anesthesia. Tricyclics can also increase sensitivity to sympathomimetics used to treat hypotension.
What this interaction means in plain words
Imipramine and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Isoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation and cardiovascular effects.
What to do
Inform the anesthesia team and monitor ECG and hemodynamics during surgery. Use vasopressors cautiously at reduced doses, and correct electrolyte disturbances.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Imipramine and Isoflurane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Imipramine with Isoflurane?
MediHelp rates the interaction as moderate. Imipramine and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval and cause hypotension, and imipramine may add to arrhythmia risk and blood pressure lability during anesthesia. Tricyclics can also increase sensitivity to sympathomimetics used to treat hypotension.
How serious is the interaction between Imipramine and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team and monitor ECG and hemodynamics during surgery. Use vasopressors cautiously at reduced doses, and correct electrolyte disturbances.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
