Drug interactions
Imipramine + Mavacamten
Severity: Moderate
Imipramine and Mavacamten: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is metabolized mainly by CYP2C19 and CYP3A4, and imipramine may weakly inhibit CYP2C19. Higher mavacamten exposure can lower ejection fraction and cause heart failure.
What this interaction means in plain words
Imipramine and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.
Why it happens
Possible inhibition of CYP2C19-mediated mavacamten metabolism by imipramine, raising mavacamten concentrations.
What to do
Monitor left ventricular ejection fraction and clinical status when imipramine is started or stopped, and adjust the mavacamten dose per labeling. Watch for heart failure symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Imipramine with Mavacamten?
MediHelp rates the interaction as moderate. Imipramine and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten is metabolized mainly by CYP2C19 and CYP3A4, and imipramine may weakly inhibit CYP2C19. Higher mavacamten exposure can lower ejection fraction and cause heart failure.
How serious is the interaction between Imipramine and Mavacamten?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor left ventricular ejection fraction and clinical status when imipramine is started or stopped, and adjust the mavacamten dose per labeling. Watch for heart failure symptoms.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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