Drug interactions
Imipramine + Metformin-pioglitazone
Severity: Minor
Imipramine and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as imipramine may alter glucose control and have occasionally been associated with hypoglycemia in patients on antidiabetic drugs. The effect is inconsistent and usually small.
What this interaction means in plain words
Imipramine and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imipramine belongs to Central Nervous System; Metformin-pioglitazone belongs to Endocrine.
Why it happens
The mechanism is not well established; tricyclics may influence insulin secretion and glucose handling.
What to do
Monitor blood glucose when imipramine is started or stopped and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Imipramine and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as imipramine may alter glucose control and have occasionally been associated with hypoglycemia in patients on antidiabetic drugs. The effect is inconsistent and usually small.
How serious is the interaction between Imipramine and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when imipramine is started or stopped and adjust antidiabetic therapy if needed.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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