Drug interactions
Imipramine + Nateglinide
Severity: Minor
Imipramine and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can alter glucose control and may add to the hypoglycemic effect of insulin secretagogues such as nateglinide. Hypoglycemia may occur unexpectedly.
What this interaction means in plain words
Imipramine and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imipramine belongs to Central Nervous System; Nateglinide belongs to Endocrine.
Why it happens
Tricyclics may enhance insulin sensitivity or secretion, an additive pharmacodynamic effect that is not fully characterized.
What to do
Monitor blood glucose when imipramine is started or stopped and reduce the nateglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Imipramine with Nateglinide?
MediHelp rates the interaction as minor. Imipramine and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants can alter glucose control and may add to the hypoglycemic effect of insulin secretagogues such as nateglinide. Hypoglycemia may occur unexpectedly.
How serious is the interaction between Imipramine and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when imipramine is started or stopped and reduce the nateglinide dose if hypoglycemia occurs.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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