Drug interactions
Imipramine + Oxazepam
Severity: Moderate
Imipramine and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination can cause additive sedation, dizziness and psychomotor impairment. Imipramine also contributes anticholinergic effects that may worsen confusion in older patients.
What this interaction means in plain words
Imipramine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from benzodiazepine GABA-A enhancement and tricyclic antihistaminic and anticholinergic activity.
What to do
Monitor for over-sedation and falls, particularly when starting or increasing doses. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Oxazepam?
MediHelp rates the interaction as moderate. Imipramine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination can cause additive sedation, dizziness and psychomotor impairment. Imipramine also contributes anticholinergic effects that may worsen confusion in older patients.
How serious is the interaction between Imipramine and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for over-sedation and falls, particularly when starting or increasing doses. Use the lowest effective doses.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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