Drug interactions
Imipramine + Palonosetron
Severity: Moderate
Imipramine and Palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rare serotonin syndrome reports exist for 5-HT3 antagonists combined with serotonergic antidepressants such as imipramine.
What this interaction means in plain words
Imipramine and Palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Palonosetron belongs to Gastrointestinal Tract.
Why it happens
Possible additive serotonergic effects; causality is not firmly established.
What to do
Monitor for agitation, tremor, clonus and hyperthermia, especially after dose changes. Discontinue and treat supportively if suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palonosetron
- Apomorphine + Palonosetron Contraindicated
- Isocarboxazid + Palonosetron Major
- Palonosetron + Phenelzine Major
- Palonosetron + Tranylcypromine Major
- Almotriptan + Palonosetron Moderate
- Amitriptyline + Palonosetron Moderate
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Palonosetron?
MediHelp rates the interaction as moderate. Imipramine and Palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rare serotonin syndrome reports exist for 5-HT3 antagonists combined with serotonergic antidepressants such as imipramine.
How serious is the interaction between Imipramine and Palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, clonus and hyperthermia, especially after dose changes. Discontinue and treat supportively if suspected.
What other medicines interact with Palonosetron?
MediHelp also lists interactions of Palonosetron with, for example, Apomorphine, Isocarboxazid, Phenelzine. The full list is on the Palonosetron page.
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