Drug interactions
Imipramine + Pazopanib
Severity: Major
Imipramine and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is associated with QT prolongation and torsades de pointes, and imipramine can also affect cardiac conduction. Pazopanib inhibits CYP2D6 and CYP3A4 weakly, which may further raise tricyclic levels.
What this interaction means in plain words
Imipramine and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imipramine belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Additive QT prolongation with possible pazopanib inhibition of CYP2D6 and CYP3A4.
What to do
Obtain a baseline and periodic ECG and monitor electrolytes, correcting potassium and magnesium. Consider an alternative antidepressant with less QT liability if QTc is prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Imipramine with Pazopanib?
MediHelp rates the interaction as major. Imipramine and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pazopanib is associated with QT prolongation and torsades de pointes, and imipramine can also affect cardiac conduction. Pazopanib inhibits CYP2D6 and CYP3A4 weakly, which may further raise tricyclic levels.
How serious is the interaction between Imipramine and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline and periodic ECG and monitor electrolytes, correcting potassium and magnesium. Consider an alternative antidepressant with less QT liability if QTc is prolonged.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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