Drug interactions
Imipramine + Pioglitazone
Severity: Minor
Imipramine and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can alter glucose control, so the effect of pioglitazone may be modestly changed. Pioglitazone alone rarely causes hypoglycemia, so the clinical impact is generally small.
What this interaction means in plain words
Imipramine and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imipramine belongs to Central Nervous System; Pioglitazone belongs to Endocrine.
Why it happens
Tricyclics may alter glucose homeostasis through a poorly characterized pharmacodynamic effect.
What to do
Monitor blood glucose when imipramine is started or stopped and adjust antidiabetic therapy if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Pioglitazone
Frequently asked questions
Can I take Imipramine with Pioglitazone?
MediHelp rates the interaction as minor. Imipramine and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants can alter glucose control, so the effect of pioglitazone may be modestly changed. Pioglitazone alone rarely causes hypoglycemia, so the clinical impact is generally small.
How serious is the interaction between Imipramine and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when imipramine is started or stopped and adjust antidiabetic therapy if control changes.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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