Drug interactions
Imipramine + Suvorexant
Severity: Moderate
Imipramine and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so the combination can increase drowsiness and impair next-day alertness, coordination and driving ability. The effect is more likely at higher doses and in older adults.
What this interaction means in plain words
Imipramine and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism and the sedating properties of imipramine.
What to do
Use the lowest effective suvorexant dose and monitor for excessive sedation. Warn the patient about driving and hazardous tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Imipramine with Suvorexant?
MediHelp rates the interaction as moderate. Imipramine and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so the combination can increase drowsiness and impair next-day alertness, coordination and driving ability. The effect is more likely at higher doses and in older adults.
How serious is the interaction between Imipramine and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective suvorexant dose and monitor for excessive sedation. Warn the patient about driving and hazardous tasks.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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