Drug interactions
Imipramine + Telavancin
Severity: Moderate
Imipramine and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine and telavancin can each prolong the QTc interval, and tricyclic antidepressants may also slow cardiac conduction. Combined use may add to the risk of ventricular arrhythmias, especially in overdose or with cardiac disease.
What this interaction means in plain words
Imipramine and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Telavancin belongs to Anti Bacterial.
Why it happens
Additive effects on cardiac repolarization and conduction.
What to do
Check a baseline ECG and monitor QTc during therapy, and correct electrolyte abnormalities. Consider an alternative antibiotic in patients with known QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Telavancin?
MediHelp rates the interaction as moderate. Imipramine and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine and telavancin can each prolong the QTc interval, and tricyclic antidepressants may also slow cardiac conduction. Combined use may add to the risk of ventricular arrhythmias, especially in overdose or with cardiac disease.
How serious is the interaction between Imipramine and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor QTc during therapy, and correct electrolyte abnormalities. Consider an alternative antibiotic in patients with known QT prolongation.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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