Drug interactions
Imipramine + Tolterodine
Severity: Moderate
Imipramine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine has strong anticholinergic activity, so combining it with tolterodine produces additive antimuscarinic effects such as dry mouth, constipation, urinary retention, blurred vision and confusion. Both can affect cardiac conduction, and imipramine may be affected by CYP2D6 competition.
What this interaction means in plain words
Imipramine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic and cardiac conduction effects.
What to do
Monitor for anticholinergic toxicity and consider an ECG in patients with cardiac risk. Where possible use a less anticholinergic antidepressant, particularly in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Tolterodine?
MediHelp rates the interaction as moderate. Imipramine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine has strong anticholinergic activity, so combining it with tolterodine produces additive antimuscarinic effects such as dry mouth, constipation, urinary retention, blurred vision and confusion. Both can affect cardiac conduction, and imipramine may be affected by CYP2D6 competition.
How serious is the interaction between Imipramine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and consider an ECG in patients with cardiac risk. Where possible use a less anticholinergic antidepressant, particularly in older adults.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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