Drug interactions
Imipramine + Zuranolone
Severity: Moderate
Imipramine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone is a CNS depressant that impairs alertness and psychomotor performance, and imipramine adds sedation. The combination can increase drowsiness, dizziness and impaired driving ability. Zuranolone labeling advises dose reduction when given with other CNS depressants.
What this interaction means in plain words
Imipramine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A positive modulation by zuranolone and the sedating effects of imipramine.
What to do
Consider reducing the zuranolone dose and counsel patients not to drive or operate machinery. Monitor for excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Imipramine with Zuranolone?
MediHelp rates the interaction as moderate. Imipramine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone is a CNS depressant that impairs alertness and psychomotor performance, and imipramine adds sedation. The combination can increase drowsiness, dizziness and impaired driving ability. Zuranolone labeling advises dose reduction when given with other CNS depressants.
How serious is the interaction between Imipramine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the zuranolone dose and counsel patients not to drive or operate machinery. Monitor for excessive sedation.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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