Drug interactions
Incobotulinumtoxina + Metaxalone
Severity: Minor
Incobotulinumtoxina and Metaxalone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skeletal muscle relaxants may add to the neuromuscular weakness produced by botulinum toxin. In theory this could increase weakness beyond the injected area, although metaxalone acts centrally and the effect is likely small.
What this interaction means in plain words
Incobotulinumtoxina and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive muscle weakness from a centrally acting muscle relaxant and a neuromuscular blocking toxin.
What to do
Monitor for excessive weakness, swallowing or breathing difficulty after injection and reduce the muscle relaxant dose if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Incobotulinumtoxina with Metaxalone?
MediHelp rates the interaction as minor. Incobotulinumtoxina and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skeletal muscle relaxants may add to the neuromuscular weakness produced by botulinum toxin. In theory this could increase weakness beyond the injected area, although metaxalone acts centrally and the effect is likely small.
How serious is the interaction between Incobotulinumtoxina and Metaxalone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive weakness, swallowing or breathing difficulty after injection and reduce the muscle relaxant dose if it occurs.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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