Drug interactions
Indacaterol inhaled + Isoproterenol
Severity: Moderate
Indacaterol inhaled and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol is a long-acting beta-2 agonist, and adding isoproterenol, a nonselective beta agonist, can potentiate sympathetic effects such as tachycardia, palpitations, tremor and arrhythmias. Hypokalemia may also be additive.
What this interaction means in plain words
Indacaterol inhaled and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-adrenergic receptor agonism, including cardiac beta-1 and beta-2 mediated effects and potassium shift.
What to do
Monitor heart rate, ECG, blood pressure and serum potassium if both are required. Avoid additional beta agonists when possible and reduce doses if cardiovascular adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoproterenol
Frequently asked questions
Can I take Indacaterol inhaled with Isoproterenol?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol is a long-acting beta-2 agonist, and adding isoproterenol, a nonselective beta agonist, can potentiate sympathetic effects such as tachycardia, palpitations, tremor and arrhythmias. Hypokalemia may also be additive.
How serious is the interaction between Indacaterol inhaled and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG, blood pressure and serum potassium if both are required. Avoid additional beta agonists when possible and reduce doses if cardiovascular adverse effects appear.
What other medicines interact with Isoproterenol?
MediHelp also lists interactions of Isoproterenol with, for example, Adrenaline-articaine, Bisoprolol, Budesonide-formoterol. The full list is on the Isoproterenol page.
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