Drug interactions
Indacaterol inhaled + Lapatinib
Severity: Minor
Indacaterol inhaled and Lapatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib may raise systemic indacaterol exposure through P-gp and CYP3A4 inhibition, and both agents can affect QTc. At the usual inhaled dose the effect is generally modest.
What this interaction means in plain words
Indacaterol inhaled and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
P-gp and CYP3A4 inhibition by lapatinib reduces indacaterol clearance, with possible additive QT effects.
What to do
No dose change is needed at standard doses; monitor for tachycardia, tremor and palpitations, and check ECG in patients with QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Indacaterol inhaled with Lapatinib?
MediHelp rates the interaction as minor. Indacaterol inhaled and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib may raise systemic indacaterol exposure through P-gp and CYP3A4 inhibition, and both agents can affect QTc. At the usual inhaled dose the effect is generally modest.
How serious is the interaction between Indacaterol inhaled and Lapatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed at standard doses; monitor for tachycardia, tremor and palpitations, and check ECG in patients with QT risk factors.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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